Long non-coding RNAs (lncRNAs) as Key Modulators of Osteogenesis in Dental and Periodontal Tissues

Abstract

A class of non-coding RNA molecules known as long non-coding RNAs (lncRNAs) has become important regulators of gene expression and particular cell functions. Studies on periodontitis and other inflammatory illnesses focused on them because of their significant role in inflammation and bone metabolism. Osteogenesis is compromised in periodontitis, a chronic inflammatory disease that causes gradual loss of alveolar bone. Our goal in this review is to provide an overview of the most recent research on the role of long noncoding RNAs (lncRNAs) in the pathophysiology of periodontal disorders and osteogenesis in dental and periodontal tissues. To identify important lncRNAs implicated in periodontal inflammation and osteogenic processes, a thorough review of recent clinical, in vitro, and in vivo investigations was carried out. According to new research, a number of lncRNAs affect inflammatory signaling pathways, which in turn affects osteoblast and osteoclast activity as well as periodontal tissue degradation. Understanding the molecular mechanisms by which these chemicals interfere can offer new perspectives on the course of disease, as well as the possible use of therapeutic targets and diagnostic biomarkers. Depending on the targeted molecule and signaling pathway, therapeutic approaches may involve either activation or inhibition of certain lncRNAs.