Advancements in Nanotechnology-Based Drug Delivery Systems for Oral Healthcare: From Traditional Practices to Personalized Medicine: A REVIEW
Keywords:
Pharmaceutics; Drug delivery system; Basic research; Application; Delivery strategyAbstract
This review comprehensively examines the transformative impact of drug delivery systems (DDS) in
oral healthcare, highlighting advancements from traditional methods to sophisticated
nanotechnology-based approaches. Focusing on various dental conditions, from caries and
periodontitis to oral cancer, the review explores the potential of nanocarriers, such as liposomes and
polymeric nanoparticles, in enhancing treatment efficacy through targeted delivery and improved
solubility. The future direction of DDS emphasizes optimizing nanoparticle release, ensuring safety,
and understanding their interaction with the oral microbiome. The evolution of DDS is traced from
early herbal remedies to modern nanoparticle-based systems, addressing key challenges in drug
delivery, including solubility and systemic side effects. Preparation methods, such as solvent casting,
hot melt extrusion, and lyophilization, are discussed for their roles in stabilizing and protecting drugs.
The review further delves into the broad applications of DDS in various medical fields, including
oncology, cardiovascular diseases, and diabetes management, and discusses the emerging trends in
personalized medicine, advanced biomaterials, and the integration of DDS with the oral microbiome.
Nanotechnology's role in dentistry, particularly in developing dental nanorobots and nanocomposites,
is highlighted, along with the significance of addressing oral pathologies with advanced DDS. The
review concludes with a discussion on the challenges and future prospects in the field, emphasizing
the need for clinical translation, co-delivery approaches, and interdisciplinary collaboration for
advancing oral and systemic healthcare.
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Copyright (c) 2024 Suzan Mohammed Abdul Raheem
This work is licensed under a Creative Commons Attribution 4.0 International License.