Fetuin-A Level in Detecting Coronary Artery Disease.

Abstract

Coronary artery disease (CAD) is the leading cause of death among cardiovascular diseases. Fetuin-A, a glycoprotein synthesized in the liver and secreted into the blood, plays roles in metabolic diseases and vascular calcification. Recent evidence also indicates that Fetuin-A is implicated in the formation of mineralo-organic nanoparticles, linking its role to nanostructural biomarkers of disease. Objectives: To determine whether Fetuin-A contributes to atherosclerosis, vascular calcification, and its potential as a nanostructural biomarker for CAD detection. The study involved 160 participants (SAP, STEMI, NSTEMI, and controls). Serum Fetuin-A, troponin T, CK-MB, lipid profile, and hsCRP were measured. Results showed that serum Fetuin-A levels were significantly reduced in CAD patients compared to controls (p < 0.0001). Conclusion: Reduced serum Fetuin-A levels may indicate severity and risk of CAD, suggesting Fetuin-A as a potential nanostructure-associated biomarker for early detection. This link between Fetuin-A and mineralo-organic nanoparticles is in line with findings on nanostructured biomedical applications.