Evaluation of Interleukine-6 Level and Genetic Variation with Celiac Disease in Iraqi Patients

Abstract

The current study aims to evaluate the association between interleukin 6 levels and gene variation with celiac disease. This study included 40 Iraqi patients with CD diagnosed based on the criteria published by the ESPGHAN guideline and 30 volunteers as healthy control Samples were collected from patients visiting the private clinic of Dr. Mustafa Al-Mashehadani in Baghdad Governorate, Iraq, the result showed the age group of patients was for all ages and for both sexes. The investigation findings exhibited that the incidence of wheat allergy in males was higher than in females, as it was (57.5%) in males and (42.5%) in females. the distribution of the age groups most CD showed that the group 1-10 years is the group most recorded a rate of (42.5%) while the last group over 31 years old was at a rate of (12.5%). The level of interleukin 6, the findings revealed that there was a significant increase (p ≤ 0.01) in the level of interleukin 6 in CD patient at a rate of 32. 13 Pg/ml compared to healthy control at a rate of 23.78 Pg/ml. According to the molecular analysis, the TT genotype is more common in celiac disease patients (66.6%) than in healthy persons (26.7%). The homozygous allele pairs (TT, CC) were detected to be (70%) higher in celiac disease patients than in healthy controls (66.6%), but the heterozygous allele pairs (TC) were (30%) lower in celiac patients than in healthy controls (33.3%).